India, US investment treaty will help businesses: Hormats | Your ...

The Bilateral Investment Treaty being negotiated between India and the US will help provide strong rules on investor protection and effective means for resolving business disputes between the two countries, the American Government has said.

The US and Indian Governments are actively engaged in Bilateral Investment Treaty (BIT) negotiations, Under Secretary for Economic Growth, Energy & Environment Robert Hormats said.

?We are aiming for a BIT that provides a high level of openness to investment across the economy, strong rules on investor protection and transparency, and effective means for resolving investment disputes,? he said at the annual India Investment Forum here yesterday.

Hormats called on Indian companies to voice support for a strong agreement that would provide them with the same protections for their investment in the US that American investors would receive in India.

?We in Government are doing our part so smart investors and corporations can continue to allocate capital, investments and people to their most productive ends.

?In order to make a robust BIT Agreement a reality, the business leaders from Mumbai and Manhattan ? perhaps even Delhi and Dallas, or Lucknow and Los Angeles ? must spearhead private sector advocacy for an agreement,? he said.

Hormats pointed out that creating a stronger US and global economy, with more jobs for Americans, is the foremost priority of the Obama Administration.

The state of the global economy still poses acute challenges and the Obama Administration remains focused on creating US jobs and help the American economy in growing faster.

?But job creation is not a zero-sum activity,? he said, adding that America will continue to focus on representing the interests of its citizens and businesses as they participate in the global economy.

?India looms large within our economic statecraft agenda. When American firms look to India, they see extraordinary promise, enviable demographics, and a business culture that celebrates innovation and entrepreneurialism. We all know the Indian economy has vast potential,? he said.

The challenges that India is seeing due to slowdown in its GDP growth, devaluation of the rupee and high inflation are surmountable, Hormats added.

He said the challenges underscore that steps toward fiscal consolidation like reducing subsidies are very important.

Source:http://www.thehindubusinessline.com/news/international/article3935130.ece

Source: http://yourdailyupdateblog.com/archives/33188

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Cellular eavesdropping made easy

Public release date: 24-Sep-2012
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Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory

New method for identifying and measuring secreted proteins over time

It is much harder to keep up with a conversation in a crowded bar than in a quiet little caf, but scientists wishing to eavesdrop on cells can now do so over the laboratory equivalent of a noisy room. A new method devised by scientists at the European Molecular Biology Laboratory (EMBL) in collaboration with the German Cancer Research Centre (DKFZ), both in Heidelberg, Germany, provides a new approach for studying the proteins cells release to communicate with each other, react to changes, or even to help them move. Published online today in Nature Biotechnology, the work also opens new avenues for drug and biomarker screening.

Cells in the lab have to be fed, and the 'serum' used to feed them contains proteins many more proteins than the cells themselves secrete, or release into their environment. So for scientists attempting to eavesdrop on cells' conversations, it's like the cells are sitting in a room bustling with impenetrable chatter until now. The new method developed by Jeroen Krijgsveld and colleagues allows scientists to distinguish proteins secreted by the cells from those in their food. And as they can measure exactly how much of each protein the cells have released, at just 2-hour intervals, scientists can see how secretion changes over time, for instance in response to changes in the cells' environment.

The EMBL scientists coax cells into using an artificial amino acid instead of the methionine they would normally employ as one of the building blocks for their proteins. The researchers can then fish out the proteins released by the cells from the surrounding serum, using a technique called click chemistry. This does away with the need to starve cells, which was so far the most reliable way of being sure you were not 'counting' proteins from the serum. And this is an important development, as the new approach showed that starving cells, even just for a few hours, affects secretion.

The double advantage of not having to starve cells and being able to follow changes over time enabled Krijgsveld and colleagues to follow, for the first time, how white blood cells called macrophages which can't be grown without serum react to a component of bacteria to kick off a rapid immune response.

"There's much more for the community to explore," Krijgsveld says: "our method could be used to watch how cells react to drug treatments; or to search for biomarkers, like the proteins cancer cells release that help them invade tissues; or to see how secretion changes if cells are grown in 3D instead of on a regular Petri dish. We've really seen a great deal of interest already."

As well as continuing to investigate the intricacies of secretion, Krijgsveld's lab now plan to use their new approach to study how cancer cells respond to drugs.

###

The work was done in collaboration with Stephan Herzig at DKFZ.

---

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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 24-Sep-2012
[ | E-mail | Share ]

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory

New method for identifying and measuring secreted proteins over time

It is much harder to keep up with a conversation in a crowded bar than in a quiet little caf, but scientists wishing to eavesdrop on cells can now do so over the laboratory equivalent of a noisy room. A new method devised by scientists at the European Molecular Biology Laboratory (EMBL) in collaboration with the German Cancer Research Centre (DKFZ), both in Heidelberg, Germany, provides a new approach for studying the proteins cells release to communicate with each other, react to changes, or even to help them move. Published online today in Nature Biotechnology, the work also opens new avenues for drug and biomarker screening.

Cells in the lab have to be fed, and the 'serum' used to feed them contains proteins many more proteins than the cells themselves secrete, or release into their environment. So for scientists attempting to eavesdrop on cells' conversations, it's like the cells are sitting in a room bustling with impenetrable chatter until now. The new method developed by Jeroen Krijgsveld and colleagues allows scientists to distinguish proteins secreted by the cells from those in their food. And as they can measure exactly how much of each protein the cells have released, at just 2-hour intervals, scientists can see how secretion changes over time, for instance in response to changes in the cells' environment.

The EMBL scientists coax cells into using an artificial amino acid instead of the methionine they would normally employ as one of the building blocks for their proteins. The researchers can then fish out the proteins released by the cells from the surrounding serum, using a technique called click chemistry. This does away with the need to starve cells, which was so far the most reliable way of being sure you were not 'counting' proteins from the serum. And this is an important development, as the new approach showed that starving cells, even just for a few hours, affects secretion.

The double advantage of not having to starve cells and being able to follow changes over time enabled Krijgsveld and colleagues to follow, for the first time, how white blood cells called macrophages which can't be grown without serum react to a component of bacteria to kick off a rapid immune response.

"There's much more for the community to explore," Krijgsveld says: "our method could be used to watch how cells react to drug treatments; or to search for biomarkers, like the proteins cancer cells release that help them invade tissues; or to see how secretion changes if cells are grown in 3D instead of on a regular Petri dish. We've really seen a great deal of interest already."

As well as continuing to investigate the intricacies of secretion, Krijgsveld's lab now plan to use their new approach to study how cancer cells respond to drugs.

###

The work was done in collaboration with Stephan Herzig at DKFZ.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-09/embl-cem092412.php

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Emmy Awards 2012: 'Homeland' Dominates

'Modern Family' and 'Game Change' also win big at ceremony hosted by Jimmy Kimmel.
By Amy Wilkinson

Damian Lewis of "Homeland" with his Emmy for Outstanding Lead Actor
Photo: Getty Images

Source: http://www.mtv.com/news/articles/1694288/emmys-2012-homeland.jhtml

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Small-Business Lessons From Harley-Davidson's Turnaround ...

This weekend, I read an article in the Wall Street Journal about how Harley-Davidson turned itself around using ?lean? manufacturing strategies. Lean, or just-in-time, manufacturing is the Toyota production system, which started with W. Edwards Deming and his work with statistical quality control. Whenever I see this kind of article about a large company, I think about how the thoughts and principles can be applied to the smaller companies I work with.

As I read this one, three things occurred to me.

1. The idea behind lean is to create capacity ? not to reduce employee headcount. In this case, Harley-Davidson reduced its headcount by more than 1,000 people using lean techniques. Harley-Davidson probably can do this just once. If it continues to use lean strategies to reduce headcount, it will see employee enthusiasm for the program wane.

People don?t want to see their jobs go, and they don?t want to see their friends? jobs go either. If the layoffs are an economic necessity, they can work. But you can only have so many economic emergencies before people say enough is enough.

My favorite use of lean is to create capacity for more business with the same headcount. I find that employees get excited and stay excited when more business comes into the company. If using lean techniques to make the company better allows for more job security through efficiencies, employees are all for it. If you cut employees in for a piece of the action through bonus programs, so much the better.

2. Installing lean in large companies is much different than installing lean in small ones. Large companies have lots of resources, both economic and human, that they can throw at arrangements like this. Small companies do not.

Still, I?m a big believer in lean activities in small companies. I?ve seen successful implementations increase profits by 50 percent or more. While large companies can afford to do more than one lean project at a time, the small company successes I?ve seen take it one step at a time.

3. Often, we see these activities led by those who have been through M.B.A. programs. The problem I often see with M.B.A.?s in smaller companies is that their educational training is for making positive changes in large companies. But those changes don?t always work in smaller companies with fewer resources. And an understanding of the strategies that do work in small companies is often totally foreign to those with advanced business degrees.

I?ve got nothing against M.B.A.?s. I?ve just come to believe that those with advanced degrees often need to have a complete reset in their beliefs about how successful change is done in a smaller company. Thankfully, there are several programs in the country that concentrate on small businesses.

I found this article very provocative. What do you think?

Josh Patrick is a founder and Principal at Stage 2 Planning Partners where he works with private business owners on wealth management issues.

Source: http://boss.blogs.nytimes.com/2012/09/24/small-business-lessons-from-harley-davidsons-turnaround/

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Apple says more than 5 million iPhone 5s sold

FILE-In this Friday, Sept. 21, 2012, file photo, a staff member of Apple Inc. shows the iPhone 5 to customers at the Apple store in Hong Kong. Apple Inc. said Monday Sept. 24 2012, that it has sold more than 5 million units of the new iPhone 5 in the three days since its launch, less than analysts had expected. (AP Photo/Kin Cheung, File)

FILE-In this Friday, Sept. 21, 2012, file photo, a staff member of Apple Inc. shows the iPhone 5 to customers at the Apple store in Hong Kong. Apple Inc. said Monday Sept. 24 2012, that it has sold more than 5 million units of the new iPhone 5 in the three days since its launch, less than analysts had expected. (AP Photo/Kin Cheung, File)

FILE- In this Friday, Sept. 21, 2012, file photo, Noah Meloccaro, right, compares his older iPhone 4s to the new iPhone 5 held by Both Gatwech, outside the Apple Store in Omaha, Neb. Apple Inc. said Monday, Sept. 24, 2012, that it sold more than 5 million units of the iPhone 5 in the three days since its launch, less than analysts had expected. (AP Photo/Nati Harnik, File)

FILE-In this Friday, Sept. 21, 2012, file photo, staff members of Apple Inc. welcome customers as the Apple store in Hong Kong started selling iPhone 5. Apple Inc. said Monday, Sept. 24, 2012, that it sold more than 5 million units of the iPhone 5 in the three days since its launch, less than analysts had expected. (AP Photo/Kin Cheung, File)

NEW YORK (AP) ? Apple Inc. said Monday that it sold more than 5 million iPhone 5s in the three days since its launch, fewer than analysts had expected.

Apple shares fell $9.30, or 1.3 percent, to close at $690.79 on Monday. The shares hit an all-time high of $705.07 Friday as the phone went on sale in the U.S., Germany, France, Japan and five other countries.

The sales tally is a record for any phone, but it beats last year's iPhone 4S launch only by a small margin. Apple said then that it sold 4 million phones in the first three days.

Topeka Capital Markets analyst Brian White expected Apple to sell 6 million to 6.5 million iPhone 5s in the first three days. He said the shortfall was largely due to limited supply. White said the phone was sold out at 80 to 85 percent of the U.S. Apple stores he and his team contacted Sunday evening, and the ones that were still available were mostly Sprint models.

Online delivery times have stretched to three to four weeks.

The phone will go on sale in 22 more countries on Friday and in more than 100 countries by the end of the year.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2012-09-24-TEC--Apple-iPhone%20Sales/id-8de8019e7c9d459d835b997cb4a6a3b8

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Facebook Groups...The New Online Dating Website

We all know that when it comes to Facebook and relationships, the two just don?t go together. Facebook has ended more relationships than Superhead did in the 90?s. In divorce proceedings facebook drama has been used as evidence. Facebook ruins lives, but it?s also beginning to enrich the lonely. I?ve realized that Facebook Groups are the new form of online dating. Join the right group and your social calendar will be filled like never before, hence a better way to meet people. The question I have is facebook dating equivalent to facebook breakups? If you allow facebook to hook you up is it easier for facebook to break you up?

I?m actually a member of a few facebook groups and I can honestly say I can see why it?s so easy for people to hook up. If you?re active in a particular group you sort of create a bond with a few members. Although you?ve probably never met most of them, you have a few that you can kick it with online. ?Based off of you pics, conversation and your relationship status the inbox pimpin begins. Now I ain?t against inbox pimpin?if anything it makes the work day go by faster, but I?ve seen and read the thirst and it amuses me. The thing about inbox pimpin is that if you?re being inboxed, imagine how many other women in the group getting the same messages from these men? Either way their messages may hit a spot and then the realness happens. Many people in these facebook groups decide to hang out on an individual basis away from the group. Now this is usually done in secret because ?they don?t want everyone all up in their business.? Now if things are cool in person that?s when the relationship starts. Either it?s a sexual one or one where they?re really trying to get to know one another outside of the internet.

A lot of these relationships turn out to be sexual ones because with all the freedom of speech in these groups, folks can tell who?s sexually frustrated and who?s not. If you exhibit frustration then chances are you will be accosted with offers of penis and whatnot. If it?s a genuine attraction then you never know what can come of it, but you also have to keep an open mind of where it possibly will not go. If you do end up in a relationship and things are beautiful then that?s wonderful. What happens if things end and you?re both still members in this group? Can you agree to FB group chat amicably? Should one person leave the group or should you both decide to leave? It can become very messy being in an open forum group with someone you had a relationship with, especially if it ended badly.

I?m not opposed to dating within Facebook, but at the same time you have to agree not to allow Facebook be the demise of your relationship. The people in these relationships allow social media *not only facebook* to ruin their relationships. Your relationship has to be stronger than the shit found on the internet. It?s so easy to get into messy shit on the internet, but you can control it if you choose to. So if you?re in search of something that can possibly fun then join one of these facebook groups. The main goal is to not expect much, but if you get something popping then enjoy it for what it is and just go with the flow. You never know where it might lead.

Holla at me: Have you ever started dating someone you met on Facebook? How did it go??

No comments yet.

Source: http://candydiaries.com/facebook-groups-the-online-dating-website/

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USC Football: Silas Redd Runs Over California As No. 13 Trojans Rebounds With 27-9 Win

LOS ANGELES ? Matt Barkley knew he wasn't exactly polishing his personal credentials while Southern California grinded out a win with its dominant defense and a steady running game.

Nobody wins the Heisman by handing off, after all.

The star quarterback wasn't thinking about his own trophy case, though, while getting the Trojans back on track for much more important rewards.

Barkley passed for 192 yards and threw two touchdown passes to Marqise Lee, and No. 13 USC bounced back from its first defeat with a 27-9 victory over California on Saturday.

Lee had 11 catches for 94 yards, Silas Redd rushed for 158 yards and a score and the Trojans (3-1, 1-1 Pac-12) methodically rolled to their ninth consecutive win over the Golden Bears (1-3, 0-1) in the schools' 100th meeting.

"I'm not looking out every week to get stats or get a flashy game," said Barkley, who threw two interceptions for the second straight week. "I think we left a lot of points on the field ... but we were moving the ball today. If defenses are going to stay back, play a cover-2 shell and force us to run, that's what we've got to do."

Did they ever: Curtis McNeal rushed 115 yards for the Trojans, giving them two 100-yard rushers in a game for the first time since 2008. USC's defense also dominated, holding Cal to 250 total yards and sacking Zach Maynard seven times.

A week after the preseason No. 1 team got shut out in the second half of a 21-14 loss at Stanford, USC drained any lingering suspense from this matchup with a methodical 75-yard drive that consumed more than half of the fourth quarter, capped by Lee's 3-yard TD catch with 5:56 to play.

"I was surprised, because they didn't have a running attack the previous game, and the previous game before that," Cal cornerback Steve Williams said. "They came out here and pounded the ball."

Barkley, meanwhile, struggled to find All-American receiver Robert Woods, who had only five catches for 30 yards.

Yet Barkley still went 22 for 34 and kept the Trojans moving on several long drives. Center Khaled Holmes' return to the lineup undoubtedly helped, although the senior limped off the field again in the fourth quarter.

"Obviously, it's not as fun," USC coach Lane Kiffin said of his workmanlike game plan. "It's fun winning 50-0, but that doesn't happen every week. Throwing the ball so much earlier in the year ... people are trying to take (Lee) and (Woods) out of the game."

Keenan Allen had nine catches for 93 yards for the Bears, who couldn't get into the Coliseum end zone. Maynard struggled to 173 yards passing with two interceptions, failing to build on a solid effort last week in Cal's narrow loss at Ohio State.

The Bears' three touted tailbacks combined for just 75 yards rushing on 17 attempts. At least kicker Vincenzo D'Amato shook off last week's struggles at Ohio State to hit three field goals for Cal.

"It's very discouraging," Allen said. "(Finishing drives) is something we talk about all week, and it's something we have to work on. You can't win a game with field goals."

Cal coach Jeff Tedford has never won at the Coliseum, and the Bears haven't beaten USC since their memorable triple-overtime win in Strawberry Canyon in 2003. Cal lost its conference opener for the fourth straight season.

"The defense made its share of plays, got some turnovers, but also let some big plays get by," Tedford said.

Stanford shut out USC for the final 41 minutes last week, but the Trojans marched straight downfield against Cal before Barkley threw an end-zone interception to Williams. They ended their scoring drought on their next drive with Redd's 33-yard TD run, the former Penn State star's fourth score in four games at USC.

"We hit them in the mouth from the first snap, and we didn't try to let our foot off the pedal," Redd said.

D'Amato, who missed three field goal attempts in Columbus last week, missed an early 35-yard try at the Coliseum, but hit his second attempt.

USC appeared to be in position to take control after Lee's TD catch capped a sharp drive early in the second quarter, but Barkley threw his second interception on a tipped pass deep in Cal territory shortly before halftime. The Trojans added a late field goal for a 17-3 lead ? not much considering they outgained Cal 300-98.

Cal pulled within 17-9 midway through the third quarter, and McNeal's fumble led to a drive deep into USC territory ? but Cal burned two timeouts on the drive before T.J. McDonald picked off Maynard's throw at the 7. After Andre Heidari made his second field goal and the USC defense forced another three-and-out, the Trojans embarked on their clock-consuming drive.

"I think it's great the way we bounced back," Barkley said. "We shut out what people were saying about us."

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Source: http://www.huffingtonpost.com/2012/09/22/usc-football-trojans-silas-redd-cal_n_1906618.html

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